E-123 Omega

E-123 Omega is an anti-hero of Sonic the Hedgehog series.

Rouge the Bat
Omega is very loyal to Rouge.

Shadow the Hedgehog
Shadow is Omega's closest friend.

Dr. Ivo "Eggman" Robotnik
Dr. Eggman is Omega's creator and greatest enemy.

Metal Sonic
Metal Sonic is Omega's enemy.

Imperator Ix
Imperator Ix is Omega's enemy.

Mephiles the Dark
Mephiles is one of Omega's greatest enemies.

Miles "Tails" Prower
Omega and Tails are close friends.

Shade the Echidna
Omega and Shade were initially enemies, because she was a member of Nocturnus Clan. However, after she left the Nocturnus Clan, Omega decided she wasn't a foe.

Sonic the Hedgehog
Omega don't consider Sonic his friend, he merely consider Sonic his ally.

G.U.N.
Omega don't consider the G.U.N. officers as his friends, he merely the G.U.N. officers as allies.

Infinite
Infinite is Omega's enemy.